Microsoft commits $60 million to the Department of Energy’s Genesis Mission, allocating $40 million for Azure compute and AI credits plus $20 million for engineering enablement services, and establishing SPARK to coordinate efforts between Microsoft and DOE. The Genesis Mission, launched by President Trump in 2025, aims to build an AI Discovery Platform linking the 17 national laboratories, their supercomputers, and vast research datasets to double US research productivity within a decade. This investment is part of a broader, multi-agency federal initiative with billions in commitments, underscoring Microsoft’s role as a key cloud and AI partner for government science. Initial projects include speeding up the discovery of energy storage materials and enabling autonomous lab work to detect biological threats, leveraging Azure to train models and run simulations. The effort signals a broad coalition of tech giants and researchers collaborating to embed AI into national science infrastructure. Together, these moves position Microsoft at the center of a long-term expansion of AI-powered federal research capabilities.