A new protocol outlines an umbrella review to identify nutrients and bioactive food components that may support brain health across the life course, aiming to move beyond deficiency prevention toward optimal cognitive and neurological outcomes. Researchers emphasize that defining brain-healthy nutrition requires linking specific dietary components to concrete brain health outcomes and may guide future trials and public health priorities. Across the articles, experts highlight that daily dietary patterns—such as fatty fish rich in omega-3s, leafy greens, berries, and nuts—can support brain function and protect against age-related cognitive decline, though no single “superfood” exists. A mouse study on lycopene suggests it may bolster dopamine signaling pathways involved in motor control, signaling potential mechanisms for dietary influence on brain health, while cautioning that results in animals do not directly translate to humans. Other sources discuss the broader cognitive benefits of omega-3s, flaxseed oil, and everyday diet patterns, reinforcing that evidence ranges from reviews to preclinical findings and that more rigorous human trials are needed. Overall, the discourse advocates a balanced, evidence-based approach to diet and brain health, avoiding sensational claims while outlining clear directions for future research and public health guidance.