Place

University of Pittsburgh

state-related research university located in Pittsburgh, Pennsylvania, United States

Also known as Western University of Pennsylvania, Pittsburgh Academy, pitt.edu, University of Pittsburgh of the Commonwealth System of Higher Education, University of Pittsburgh- Of the Commonwealth System of Higher Education, University of Pittsburgh-Of the Commonwealth System of Higher Education

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In the news

Researchers Reveal 3D Genome Folding Linked to Alzheimer's Brain Changes

Multiple studies from CMU, Pitt, and UW connect Alzheimer's pathology to changes in the genome’s 3D architecture, linking genome folding to gene activity with advanced techniques like GAGE-seq and the Hicformer AI model to map these changes in brain tissue. Additional work highlights age-related genome regulation shifts, including microglial turnover and blood-brain barrier cell decline, alongside a mid-stage drug trial where an anti-tau therapy showed potential to slow cognitive decline, underscoring 3D genome remodeling as a core facet of disease and aging beyond amyloid and tau alone.

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Key facts

Country: United States
Headquarters: Pittsburgh
Inception: 1787
Website: https://www.pitt.edu

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