amyotrophic lateral sclerosis.
rare neurodegenerative disease with amyotrophy and progressive paralysis
Actor Eric Dane Succumbs to ALS at 53
Actor Eric Dane, known for his role in “Gray’s Anatomy,” has died from amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s Disease. He was 53. Dane died Thursday, People reported, citing a statement from…
Reporting · 1 source · Feb 20, 2026Read it
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About amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), Lou Gehrig's disease or Charcot's disease, is a rare terminal neurodegenerative disease defined by the progressive loss of both upper and lower motor neurons that normally control voluntary muscle contraction. ALS is the most common of the motor neuron diseases. ALS often presents with gradual muscle stiffness, twitches, weakness, and wasting. Motor neuron loss typically continues until the ability to eat, speak, move, and breathe without mechanical support is lost. At least 50% of people with ALS experience significant changes in thinking and behavior, with 15% of individuals going on to develop frontotemporal dementia. An ALS diagnosis is made based on a person's signs and symptoms, with additional testing conducted to rule out other potential causes. Depending on which areas of the body are affected first, ALS may be classified as limb-onset or bulbar-onset. Respiratory onset occurs in approximately 1–3% of cases.
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