Prescott is a masculine given name. Bearers of the name include:
Prescott E. Bloom (1942–1986), American lawyer and politician
Prescott Burgess (born 1984), American former National Football League player
Prescott Bush (1895–1972), American banker and politician, father of President George H. W. Bush and grandfather of President George W. Bush and ex-governor Jeb Bush
Prescott F. Cogswell (1859–1960), American politician
Prescott Durand Crout (1907–1984), American mathematician
Prescott Currier (1912–1995), American naval officer and cryptanalyst
Prescott F. Hall (1868–1921), American lawyer, author and eugenicist
Prescott Gardner Hewett (1812–1891), British surgeon and serjeant-surgeon extraordinary to Queen Victoria
Prescott B. Huntington (1905–1988), American politician
Prescott Lecky (1892–1941), American psychologist
Prescott Metcalf, American businessman and 8th mayor of Erie, Pennsylvania
Prescott Niles, American rock bassist
Prescott Townsend (1894–1973), American gay rights activist
Prescott Wright (1935–2006), American animated film producer and distributor