Yang Shi.

About Yang Shi

Yang Shi is a molecular biologist known for work on epigenetic regulation, particularly histone and RNA methylation. He is a Member of the Ludwig Institute for Cancer Research and a professor at the University of Oxford. Shi is best known for his discovery of lysine-specific demethylase 1 (LSD1/KDM1A) in 2004, which demonstrated that histone methylation is reversible. His work has identified multiple histone demethylases and clarified their roles in gene regulation, cancer, and human disease, and has contributed to the ongoing development of epigenetic cancer therapies. He is an elected member of the National Academy of Sciences, the National Academy of Medicine, and the Royal Society, and a recipient of the Leopold Griffuel Prize.