From 1768 to 1772 one of the leaders of the Bar Confederation, considered by some to be the first Polish uprising[1]. It was formed by Polish nobility who opposed Russian intervention into Polish internal politics; Krasiński also criticized the Holy See for its silence on the matter of arrest of several Polish nobles during that time, including two bishops (Kajetan Ignaty Sołtyk and Józef Andrzej Załuski, by the Russians. In the Bar Confederation he became their most important diplomat, responsible for many negotiations and their relations with foreign powers. In October 1768 he went to Paris where he was received by King Louis XV who promised support for the confederates.
In 1769 he advocated the assassination of King Poniatowski, later that year he became the head of the confederate's government in Biała. In 1770 he went to Dresden to gain support from the Holy Roman Empire; later that year he met Joseph II, Holy Roman Emperor and received an offer of help from him. Also he did not support the declaration that King Poniatowski is not the legitimate king of Poland, he nonetheless supported Frederick Augustus I of Saxony as a counter-candidate.
He was likely one of the supporters or even the ring-leader of the plan to kidnap Poniatowski, eventually carried by Casimir Pulaski in 1771. That plan nonetheless backfired, as Poniatowski not only escaped but this action caused much controversy in Europe and resulted in loss of much international support for the confederates. Eventually in 1772 he began negotiations with the King about surrender of the confederates; later that year he himself was kidnapped by the Cossacks and temporarily imprisoned in Warsaw. He was nonetheless set free after he pledged loyalty to the king and regained his posts in the Polish–Lithuanian Commonwealth.
After 1772, he distanced himself from political life until the reforms of the late 1780s. In 1780, 1782, 1784 and 1786 he was the president of the Sejm court. In 1787 ordered the reconstruction of fortress in Kamieniec. During the Great Sejm, he was one of the most active supporter of the Constitution of 3 May 1791, publishing projects and papers supporting it, and eventually taking part in the semi-coup that resulted in its declaration. Notably, he commented on behaviour of one of the constitution opponents, Jan Sucharzewski (who threatened to kill himself and his young son to 'spare them the fate of living under this restrictive law') saying 'shave his head and send him to the asylum'. Vocal opponent of Targowica Confederation, which after its victory punished him by abolishing his diocese. Supporter of Kościuszko Uprising; he collected funds for the uprising. After its defeat, he left political life again, eventually moving to the Prussian partition. He died in October 1800 in Krasne.