Alcalde is a Spanish surname related to alcalde, the Spanish title for a mayor. Notable people with the name include:
Antonio Alcalde Barriga (1701–1792), Spanish Catholic prelate and bishop
Cristina Alcalde (born 1980), Spanish cyclist
Gustavo Alcalde (born 1955), Spanish politician
Jorge Alcalde (1911–2005), Peruvian footballer
Jorge Alcalde Lagranja (born 1968), Spanish journalist, science advocate and writer
Luisa María Alcalde Luján (born 1987), Mexican politician
Manuel Alcalde (1956–2004), Spanish race walker
Mario Alcalde (1926–1971), American actor
M. Cristina Alcalde, Peruvian anthropologist and academic
Moisés Alcalde Virgen (born 1971), Mexican politician
Núria Aliaga-Alcalde, Spanish chemist and academic
Pedro Alcalde (born 1959), Spanish musician, composer and conductor
Tati Alcalde (born 1964), Spanish footballer
Teodoro Alcalde (1913–1995), Peruvian footballer
Zenaida Alcalde (born 1981), Spanish circus performer, actress and teacher