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Alison Sinclair

researcher

Alison Sinclair

researcher

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About Alison Sinclair

Alison Jane Sinclair is professor of molecular virology at the University of Sussex where she runs the Sinclair Lab. Her research interests include the Epstein Barr virus. She is a fellow of the Royal Society of Biology and a senior fellow of the Higher Education Academy.

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Occupation: researcher, virologist
Citizenship: United Kingdom
Born: 2000

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bZIP proteins of human gammaherpesviruses.Induction of p16(INK4a) is the major barrier to proliferation when Epstein-Barr virus (EBV) transforms primary B cells into lymphoblastoid cell lines Strain variation in Epstein-Barr virus immediate early genes.Dynamic chromatin environment of key lytic cycle regulatory regions of the Epstein-Barr virus genome Epigenetic control of viral life-cycle by a DNA-methylation dependent transcription factor DNA-damage response pathways triggered by viral replication.Genome-wide analyses of Zta binding to the Epstein-Barr virus genome reveals interactions in both early and late lytic cycles and an epigenetic switch leading to an altered binding profile Mutation of a single amino acid residue in the basic region of the Epstein-Barr virus (EBV) lytic cycle switch protein Zta (BZLF1) prevents reactivation of EBV from latency United Kingdom

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