Alma-Tadema is a surname. Notable people with the surname include:
Lawrence Alma-Tadema (1836–1912), Dutch painter
Laura Theresa Alma-Tadema (1852–1909), English painter and second wife of Sir Lawrence
Laurence Alma-Tadema (1865–1940), novelist and poet; Sir Lawrence's first daughter
Anna Alma-Tadema (1867–1943), painter; Sir Lawrence's second daughter