CNN
Cooper left The Mole after its second season to return to broadcast news. In 2001, he joined CNN, commenting, "Two seasons was enough, and 9/11 happened, and I thought I needed to be getting back to news." His first position at CNN was to anchor alongside Paula Zahn on American Morning. In 2002, he became CNN's weekend prime-time anchor. Since 2002, he has hosted CNN's New Year's Eve special from Times Square.
On September 8, 2003, Cooper became the anchor of Anderson Cooper 360° on CNN. Describing his philosophy as an anchor, he has said:
I think the notion of traditional anchor is fading away, the all-knowing, all-seeing person who speaks from on high. I don't think the audience really buys that anymore. As a viewer, I know I don't buy it. I think you have to be yourself, and you have to be real and you have to admit what you don't know, and talk about what you do know, and talk about what you don't know as long as you say you don't know it. I tend to relate more to people on television who are just themselves, for good or for bad, than I do to someone who I believe is putting on some sort of persona. The anchorman on The Simpsons is a reasonable facsimile of some anchors who have that problem.
In 2005, Cooper covered the tsunami damage in Sri Lanka; the Cedar Revolution in Beirut, Lebanon; the death of Pope John Paul II; and the royal wedding of Prince Charles and Camilla Parker Bowles. In August 2005, he covered the Niger famine from Maradi.
In 2005, during CNN coverage of the aftermath of Hurricane Katrina, he confronted Sen. Mary Landrieu, Sen. Trent Lott, and the Reverend Jesse Jackson about their perception of the government response. As Cooper said later in an interview with New York magazine, "Yeah, I would prefer not to be emotional and I would prefer not to get upset, but it's hard not to when you're surrounded by brave people who are suffering and in need." A contributor to Broadcasting & Cable magazine wrote: "In its aftermath, Hurricane Katrina served to usher in a new breed of emo-journalism, skyrocketing CNN's Anderson Cooper to superstardom as CNN's golden boy and a darling of the media circles because of his impassioned coverage of the storm."
In September 2005, the format of CNN's NewsNight was changed from 60 to 120 minutes to cover the unusually violent hurricane season. To help distribute some of the increased workload, Cooper was temporarily added as co-anchor to Aaron Brown. This arrangement was reported to have been made permanent the same month by the president of CNN's U.S. operations, Jonathan Klein, who has called Cooper "the anchorperson of the future". Following the addition of Cooper, the ratings for NewsNight increased significantly; Klein remarked that "[Cooper's] name has been on the tip of everyone's tongue." To further capitalize on this, Klein announced a major programming shakeup on November 2, 2005. Cooper's 360° program would be expanded to two hours and shifted into the 10:00 pm ET slot formerly held by NewsNight, with the third hour of Wolf Blitzer's The Situation Room filling in Cooper's former 7:00 pm ET slot. With "no options" left for him to host shows, Aaron Brown left CNN, ostensibly having "mutually agreed" with Jonathan Klein on the matter.
In early 2007, Cooper signed a multi-year deal with CNN that would allow him to continue as a contributor to 60 Minutes, as well as doubling his salary from $2 million annually to a reported $4 million.
On April 16, 2023, CNN launched a new Sunday primetime series, The Whole Story with Anderson Cooper.
In 2007, he began hosting CNN Heroes: An All-Star Tribute, a show about extraordinary deeds by ordinary people.
In October 2007, Cooper began hosting the documentary Planet in Peril with Sanjay Gupta and Jeff Corwin on CNN. In 2008, Cooper, Gupta, and Lisa Ling from National Geographic Explorer teamed up for a sequel, Planet in Peril: Battle Lines, which premiered in December 2008.
In September 2010, Warner Bros. and Telepictures (both corporate siblings of CNN) announced that Cooper had signed an agreement to host a nationally syndicated talk show. The journalist Brian Stelter (at the time employed by The New York Times, and now by CNN), reported on Twitter that the new Warner Bros. daytime talk show would be named Anderson (now titled Anderson Live). The show premiered on September 12, 2011, and as part of negotiations over the talk show deal, Cooper signed a new multi-year contract with CNN to continue as the host of Anderson Cooper 360°. On October 29, 2012, it was announced that Anderson Live would end at the conclusion of its second season. The show, slightly renamed after season one and revamped with a variety of co-hosts, failed to achieve the ratings distributor Warner Brothers hoped for. The final Anderson Live aired on May 30, 2013.
Along with Martha Raddatz, Cooper moderated the second presidential election debate between Hillary Clinton and Donald Trump. This made him the first LGBT person to moderate a presidential debate in the general election.
In 2017, Cooper's close friend, Andy Cohen, joined Cooper in succeeding Kathy Griffin as co-host of CNN's New Year's Eve coverage. They again co-hosted CNN's New Year's Eve for 2018, 2019, 2020, 2021, 2022, 2023 and 2025.