Anna Palaiologina was a queen-consort of the Despotate of Epirus as wife of John II Orsini. She was regent for her son Nikephoros II Orsini in 1337–1338. She later married the Lord of Valona, John Komnenos Asen.
- Occupation
- politician, regent
- Position held
- regent, despotissa
- Citizenship
- Byzantine Empire
- Born
- 1400