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ARAF

protein-coding gene in the species Homo sapiens

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About ARAF

Serine/threonine-protein kinase A-Raf, or simply A-Raf, is an enzyme that in humans is encoded by the ARAF gene. It belongs to the Raf kinase family of serine/threonine-specific protein kinases, which also includes Raf-1 and B-Raf. A-Raf is involved in the MAPK/ERK pathway, where it contributes to cell signaling processes that regulate proliferation, survival, and differentiation. Compared to Raf-1 and B-Raf, A-Raf is less well studied and exhibits distinct structural and regulatory features, including low kinase activity and alternative splicing in cancer. In addition to its role in MAPK signaling, A-Raf has functions in apoptosis suppression, cancer metabolism, and endocytic trafficking.

Facts from Wikidata (CC0). Image by Emw via Wikimedia Commons (CC BY-SA 3.0).

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On Watch

Palestinian-American UFC fighter Sean Sharaf wore his traditional Keffiyeh inside the Octagon after securing an 11-second knockout victory. Following the win, Sharaf declared: "Free Palestine, the people are hurting out there. We just want to see them free."Arab News

In the Arcade

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Studio characters

Vincenzo CarafaOff script, off duty, unreasonably available.Paul CarafotesThe American actor doing a table read of your day.Vibha SarafThe Indian singer-songwriter, humming something new at you.

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