Plot
Four years after the death of Isabel Aretas, MPD Detective Mike Lowrey marries his physical therapist, Christine. During the reception, his partner, Detective Marcus Burnett, suffers a heart attack and goes into a coma, where he experiences a vision of the late Captain Conrad Howard telling him it is not his time. When Marcus wakes up, he believes that he cannot die.
Conspirators forced a Miami-based money launderer to transfer a large sum to Captain Howard's account and fabricate extensive transaction records before he was assassinated. News reports soon link Howard to a cartel. With his legacy being posthumously tarnished, Mike and Marcus, with the help of Captain Rita Secada and her boyfriend, mayoral candidate Adam Lockwood, aim to prove Howard's innocence. They visit Mike's son, Armando Aretas, who was imprisoned for Howard's death. Armando reveals that Howard wasn't corrupt but understood who was, and was killed to keep their secrets, and agrees to help identify the killer.
When the conspirators try to access Captain Howard's computer, a fail-safe, pre-recorded video is sent to Mike and Marcus, warning them of an extensive corruption scheme within law enforcement. Howard uses the phrase "Coke bottle" as a code phrase, and it is revealed that he gave information to their former hacker colleague Fletcher. They go to Fletcher's club to retrieve the "files", a QR code hidden in wall art that unlocks a second video from Captain Howard. However, assassins hired by the conspirators tail them to the club and kill Fletcher.
Meanwhile, Armando is attacked by several prisoners, paid to silence him, but he fends them off. Mike and Marcus arrange for Armando to be air-lifted to a more secure location in Miami. However, the conspirators sneak on board and kill the pilot and guards, causing the helicopter to crash. Mike, Marcus, and Armando survive but are branded as fugitives by the conspirators. When the conspirators put out a bounty, the trio are hunted by both law enforcement and opportunistic criminals. Conrad's daughter, U.S. Marshal Judy Howard, swears vengeance on Armando for killing her father.
With the assistance of AMMO (Advanced Miami Metro Operations) members Dorn and Kelly, Mike and Marcus uncover the video clues behind the murder and setup. Armando identifies the man who hired him to kill Captain Howard as James McGrath, a former Army Ranger assigned to Drug Enforcement Administration Intelligence in South America. While undercover, McGrath was captured by the cartel and brutally tortured until he gave up his associates and has been working with them ever since. McGrath orchestrates the abduction of Christine and Callie, Judy's daughter. He then sends his men to get Marcus's family, but Marcus's Marine son-in-law, Reggie, single-handedly kills all of them. Rita, Dorn, and Kelly apprehend Lockwood after learning McGrath works for him. By using Lockwood's voice in disguise to draw out McGrath by arranging for a transport plane out of Miami, the team engages in a fierce gun battle with McGrath's men at a former alligator-themed amusement park to rescue Christine and Callie. Later on, during the fight, Lockwood attempts to betray the team by wounding Dorn and Kelly before attempting to hijack the transport plane, but Rita shoots the plane down and stops him. Refusing to shoot him, she kicks him into the water, causing him to be devoured alive by an alligator. Mike confronts McGrath, who holds both Christine and Marcus hostage at gunpoint. McGrath then presents Mike with an impossible choice: pick Christine or Marcus to die. Mike, alluding to Marcus's newfound belief that he "cannot die", shoots Marcus in his bulletproof vest. The chaos allows Christine and Marcus to break free before Mike shoots McGrath dead. Amidst the chaos, Judy finds Armando and Callie. Judy prepares to kill Armando, but Callie tells her mother that he saved her life. Begrudgingly grateful for his heroic act, Judy shows mercy to Armando and allows him to escape.
Afterward, Mike, Marcus, and Howard are cleared of all charges, and the corruption is exposed. Mike and Marcus's families then celebrate by having a picnic in the park, with Mike and Marcus allowing Reggie to cook on a public grill due to him saving their family.