International breakthrough
In 2014, Wong played Kublai Khan in the Netflix series Marco Polo, which on 7 January 2015 was renewed by Netflix for a 10-episode second series. The next year, he appeared in another Ridley Scott science fiction film, playing Jet Propulsion Lab director Bruce Ng in The Martian. In 2016, he co-starred as Wong in the superhero film Doctor Strange (2016) and later reprised the role in Avengers: Infinity War (2018), Avengers: Endgame (2019), Shang-Chi and the Legend of the Ten Rings (2021), Spider-Man: No Way Home (2021), Doctor Strange in the Multiverse of Madness (2022), and the 2022 Disney+ series She-Hulk: Attorney at Law.
He appeared in Hated in the Nation, an episode of the anthology series Black Mirror, playing Shaun Li, an agent with the National Crime Agency in 2016. In 2017 he voiced Alex Yu in the Arkane Studios game Prey and starred in 2036: Nexus Dawn, a promotional short film prequel to Blade Runner 2049 directed by Luke Scott and co-starring Jared Leto. He appeared as the scientist Lomax in the 2018 science fiction horror film Annihilation.
In 2019, he performed the voice of Skeksis general skekVar in the Netflix series The Dark Crystal: Age of Resistance and the voice of Bull in the film Lady and the Tramp. In 2020, he appeared as a Necromancer in an episode of the FX television series What We Do in the Shadows. Wong's 2013 political play #aiww: The Arrest of Ai Weiwei was streamed through the news network The Guardian again in May 2020.
In 2021, Wong voiced the warrior giant Tong in the Disney animated film Raya and the Last Dragon. In 2021, he was nominated for a Spirit Award for Best Supporting Male for his performance as Kyo in Nine Days. He joined the cast of the Netflix live action adaptation of the Chinese novel The Three Body Problem by Liu Cixin, which began shooting later that year. In 2022, through BBC Radio, he partnered with Ai WeiWei again as the narrator for Ai's memoir 1000 Years of Joys and Sorrows. In 2024, 3 Body Problem was released. The show was well received, with Wong's performance being singled out.