2000s
In 2000, Big Daddy Kane appeared on Tony Touch's "The Piece Maker" mixtape alongside Kool G Rap and KRS-One. A rejuvenated Kane occasionally collaborated with a variety of hip-hop artists, including A Tribe Called Quest, Jurassic 5, Little Brother, and DJ Babu of the Beat Junkies. He released two singles, the Alchemist-produced "The Man, The Icon", and the DJ Premier-produced "Any Type of Way" (on which he discusses urban collapse in post-9/11 New York City ("Giuliani got New York lookin' like it's Amistad") and the erosion of the middle class.
Big Daddy Kane appeared on the trip hop group Morcheeba's 2003 single "What's Your Name".
In 2005, Big Daddy Kane was honored during the VH1 Hip-Hop Honors. After a medley of hits performed by T.I., Black Thought, and Common, he came out to perform "Warm It Up, Kane" with his old dancers, Scoob and Scrap. Kane and Kool G Rap can both be seen briefly in Dave Chappelle's Block Party.
In 2006, he appeared as a guest MC on the track "Get Wild Off This", produced by the Stanton Warriors for their Stanton Sessions Vol. 2 breaks mix. He also appeared alongside the Wu-Tang Clan, Rakim, Busta Rhymes, and Q-Tip in a segment of the 2006 Summer Jam concert (June 7, 2006), as part of an initiative by Busta Rhymes to honor the legacy of New York City hip-hop.
In 2007, a new track, "BK Mentality", was released on the mixtape compilation Official Joints. Kane also appeared on Joell Ortiz's The Brick: Bodega Chronicles mixtape.
Big Daddy Kane made a cameo in the 2008 video for "Game's Pain" by The Game. The video also featured Raekwon, Three 6 Mafia and Ice Cube. Kane also appeared on the remix of "Don't Touch Me" by Busta Rhymes. Also in 2009, Kane played the role of Clay in the film Just Another Day. The film follows two rappers, one poor and young, one older and successful, through a day in their lives.