Early Hollywood career
Once Karloff arrived in Hollywood, he appeared in small roles in dozens of silent films, but the work was sporadic and he often had to take up manual labour such as digging ditches or delivering construction plaster to make ends meet. (According to Karloff, his first film was a Frank Borzage picture at Universal for which he received $5 as an extra; the title of this film has never been traced.)
His first certain screen role was in a film serial, The Lightning Raider (1919) with Pearl White. He was in another serial that same year, The Masked Rider (1919), the earliest of his film appearances that has survived. Karloff could also be seen in His Majesty, the American (1919) with Douglas Fairbanks, The Prince and Betty (1919), The Deadlier Sex (1920) with Blanche Sweet, and The Courage of Marge O'Doone (1920). He played an Indian in The Last of the Mohicans (1920) with Wallace Beery and he would often be cast as an Arab or Indian in his early films.
Karloff's first major role came in a film serial, The Hope Diamond Mystery (1920). He was Indian in Without Benefit of Clergy (1921) and an Arab in Cheated Hearts (1921) and villainous biracial hired hand in The Cave Girl (1921). He was a maharajah in The Man from Downing Street (1922), a Nabob in The Infidel (1922) and had roles in The Altar Stairs (1922), Omar the Tentmaker (1922) (as an Imam), The Woman Conquers (1922), The Gentleman from America (1923), The Prisoner (1923) and the serial Riders of the Plains (1923).
Karloff did a Western, The Hellion (1923), and a drama, Dynamite Dan (1924). He could be seen in Parisian Nights (1925), Forbidden Cargo (1925), The Prairie Wife (1925) and the serial Perils of the Wild (1925). Karloff went back to bit part status in Never the Twain Shall Meet (1925), directed by Maurice Tourneur, but he had a good support part in Lady Robinhood (1925) starring Evelyn Brent in the titular role.
Karloff went on to be in The Greater Glory (1926), Her Honor, the Governor (1926), The Bells (1926) (as a mesmerist), The Nickel-Hopper (1926) with Mabel Normand, The Golden Web (1926), The Eagle of the Sea (1926), Flames (1926), Old Ironsides (1926) with Wallace Beery and Esther Ralston, Flaming Fury (1926), Valencia (1926), The Man in the Saddle (1926) with Hoot Gibson, Tarzan and the Golden Lion (1927) (as an African), Let It Rain (1927), The Meddlin' Stranger (1927), The Princess from Hoboken (1927), The Phantom Buster (1927) with Buddy Roosevelt, and Soft Cushions (1927).
Karloff had roles in Two Arabian Knights (1927), The Love Mart (1927) with Noah Beery Sr., The Vanishing Rider (1928) (a serial), Burning the Wind (1928), Vultures of the Sea (1928), and The Little Wild Girl (1928).
He was in The Devil's Chaplain (1929), The Fatal Warning (1929) for Richard Thorpe, The Phantom of the North (1929), Two Sisters (1929), Anne Against the World (1929), Behind That Curtain (1929) with Warner Baxter, and The King of the Kongo (1929), a serial directed by Thorpe.
One day while he was sitting at a bus stop in the pouring rain, Lon Chaney Sr., 'The Man of a Thousand Faces', spotted Karloff and offered him a ride. Chaney told him to "find something different that will set you apart and is different from anything someone else has done or is willing to do and do it better".
Karloff had an uncredited bit part in The Unholy Night (1930) directed by Lionel Barrymore, and bigger parts in The Bad One (1930), The Sea Bat (1930) starring Charles Bickford and directed by Lionel Barrymore and Wesley Ruggles, and The Utah Kid (1930) directed by Thorpe.
A film which brought Karloff recognition was The Criminal Code (1931), a prison drama directed by Howard Hawks in which he reprised a dramatic part he had played on stage. In the same period, Karloff had a supporting role as a mob boss in Hawks' gangster film Scarface starring Paul Muni and George Raft, but the film was not released until 1932 because of censorship problems.
He did another serial for Thorpe, King of the Wild (1931), then had support parts in Cracked Nuts (1931) with Wheeler and Woolsey, Young Donovan's Kid (1931) with Jackie Cooper, Smart Money (1931) with Edward G. Robinson and James Cagney in their only film together, The Public Defender (1931) with Richard Dix, I Like Your Nerve (1931) with Douglas Fairbanks Jr. and Loretta Young, and Graft (1931) with Regis Toomey and future agent Sue Carol.
Another significant role in the autumn of 1931 saw Karloff play a key supporting part as an unethical newspaper reporter in Five Star Final with Edward G. Robinson, a film about tabloid journalism which was nominated for the Academy Award for Best Picture.
He could also be seen in The Yellow Ticket (1931) with Elissa Landi, Lionel Barrymore and Laurence Olivier during Olivier's memorable first round in Hollywood, The Mad Genius (1931) with John Barrymore, The Guilty Generation (1931) with Robert Young and Tonight or Never (1931) with Gloria Swanson.