Brescia or da Brescia is a surname derived from the city of Brescia in Italy. Notable people with the surname include:
Alfonso Brescia (1930–2001), film director
Domenico Brescia (1866–1939), composer
Fortunato Brescia Tassano (d. 1951), Italian-born Peruvian businessman
Georgia Brescia (born 1996), Italian tennis player
Giovanni Antonio da Brescia, Italian painter
Giovanni Maria da Brescia, Italian painter
Jason Michael Brescia (born 1986), American comedy writer-director
Justin Brescia (born 1982), American actor
Leonardo Brescia (1520–1582), Italian painter
Lisa Brescia (born 1970), American actress
Mario Brescia Cafferata (1929–2013), Peruvian billionaire businessman
Moretto da Brescia (c. 1498–1554), Italian painter
Pedro Brescia Cafferata (1921–2014), Peruvian businessman
Rosa Brescia Cafferata (born c. 1926), Peruvian billionaire heiress and philanthropist