Brush is a surname. Notable people with the surname include:
Charles F. Brush (1849–1929), American inventor
George de Forest Brush (1855–1941), American painter
George Jarvis Brush (1831–1912), American mineralogist
Henry Brush (1778–1855), American legislator
Jared M. Brush (1814–1895), American politician, former mayor of Pittsburgh, Pennsylvania
Joey Brush (1955–2015), American politician
John T. Brush (1845–1912), American baseball executive
Katharine Brush (1902–1952), American author
Kathryn Brush, Canadian historian and distinguished professor of art history
Paul Brush (born 1958), English footballer
Rhys Brush, American football player
Richard Brush (born 1984), English footballer