Cardinal-Infante Afonso was a Portuguese infante (prince), son of King Manuel I of Portugal and his wife Maria of Aragon.
- Occupation
- Catholic priest
- Position held
- cardinal, Roman Catholic Archbishop of Lisbon, Roman Catholic Archbishop of Evora, Roman Catholic Bishop of Viseu
- Citizenship
- Kingdom of Portugal
- Born
- April 23, 1509
- Died
- April 21, 1540, April 16, 1540