Career
Keener had a supporting role as Lt. Cricket Sideris in the television series Ohara. The series ran from January 1987 to May 1988.
Her first film appearance was one line in About Last Night... (1986) and three years later she appeared in Survival Quest.
She guest starred as an artist on an episode of Seinfeld called "The Letter", playing Jerry's girlfriend, an artist who painted a famous portrait of Kramer. Keener then earned her first starring role, in Johnny Suede, with the then-unknown Brad Pitt. Her performance gained critical acclaim and earned her first Independent Spirit Award nomination for Best Female Lead. She went on to work with director Tom Dicillo again, in Living in Oblivion (1995). Two years later, she was once again nominated for an Independent Spirit Award for her performance in Walking and Talking, an independent cult-comedy film directed by Nicole Holofcener.
In 2000, Keener earned her first Oscar nomination for Best Supporting Actress for her role in Being John Malkovich, directed by Spike Jonze. In 2001, she worked with director Nicole Holofcener in Lovely and Amazing, garnering her a third Independent Spirit Award nomination. In 2002, she co-starred with Edward Norton in the off-Broadway revival of Burn This and the film Death to Smoochy. She also took part in the film Full Frontal, and Simone alongside Al Pacino.
In 2005, she starred in the political thriller The Interpreter (as a Secret Service agent partnered with Sean Penn's character) and The Ballad of Jack and Rose with Daniel Day-Lewis and played the love interest of Steve Carell in Judd Apatow's The 40-Year-Old Virgin. Keener's performance as writer Harper Lee in Capote (also 2005) earned her several awards and nominations, including her second Oscar nomination for Best Supporting Actress. In 2006, she starred in the film Friends with Money, directed by Nicole Holofcener.
In 2007, Keener played Jan Burres in Sean Penn's critically acclaimed film Into the Wild, based on Jon Krakauer's best-selling book of the same name. In 2008, her film An American Crime, the true story of Gertrude Baniszewski, a middle-aged mother who tortured and murdered Sylvia Likens in her Indiana home, was aired on Showtime. Keener played Baniszewski and her portrayal earned her an Emmy nomination in the Best Actress in a TV Mini-Series or Movie category. In 2008, Keener portrayed Philip Seymour Hoffman's wife Adele in Charlie Kaufman's directorial debut, Synecdoche, New York. She and Hoffman again played husband and wife in the 2012 film A Late Quartet. Keener played the title character's mother in the 2010 film Percy Jackson & the Olympians: The Lightning Thief, based on the series of books by Rick Riordan.
Keener starred in the six-episode HBO miniseries Show Me a Hero, based on the 1999 nonfiction book of the same name by Lisa Belkin. It aired in August 2015. In 2016, Keener starred in the independent film Unless.
In 2017, Keener starred as Missy Armitage in the racially themed horror film Get Out, which was a critical and commercial success.
Keener starred in the 2021 Netflix horror drama miniseries Brand New Cherry Flavor.
In 2024, Keener appeared in Joker: Folie à Deux, the sequel to the 2019 film Joker.
