Clendenin is a surname. Notable people with the surname include:
David Clendenin (fl. 1800s–1810s), American investor, soldier, and politician
David Ramsay Clendenin (1830–1895), American Union Army officer
John J. Clendenin (1813–1876), justice of the Arkansas Supreme Court
John L. Clendenin (1934–2020), American businessman
Michael Clendenin (1934–2017), American journalist