Cobham is a surname. Notable people with the surname include:
Sir Alan Cobham, aviation pioneer
Alan Cobham (mathematician), the namesake of Cobham's thesis in the computational complexity theory
Anne Brooke, Baroness Cobham (1501–1558), English aristocrat and reported accuser of Queen Anne Boleyn
Billy Cobham (born 1944), jazz musician
Catherine Cobham, British translator
David Cobham, British film and television producer
Eleanor, Duchess of Gloucester, née Cobham, accused witch
Eric Cobham, an early 18th-century pirate
George Cobham, multiple people
Henry Cobham, multiple people, including:
Henry de Cobham, 1st Baron Cobham (1260–1339), English peer
John Cobham, multiple people
Reginald de Cobham, 1st Baron Cobham (1295–1361), English knight and diplomat
Thomas Cobham, multiple people
Tilda Cobham-Hervey (b. 1994), Australian actress