2000s and 2010s
In 2004, Argento directed The Card Player, a giallo about a killer whose murders are conducted during Internet poker matches with the Rome police, which earned a mixed reception; some fans appreciated the techno music score composed by ex-Goblin member Claudio Simonetti, but felt the film was too mainstream, with little of Argento's usual flourish.
In the 2005 TV broadcast of Argento's Do You Like Hitchcock?, the director paid homage to Alfred Hitchcock after decades of being compared to him by critics. Later that year, he directed an episode of Masters of Horror, a Showtime television series, called "Jenifer". For season two of the series, Argento directed "Pelts", an adaption of the F. Paul Wilson short story of the same name.
In 2007, Argento finished the final film of his Three Mothers trilogy, The Mother of Tears, which is set in Rome and centres on the titular "third mother", Mater Lacrimarum. Argento and Jace Anderson share writing credits for the film. Asia Argento was cast as the lead player, along with her mother and frequent Argento collaborator Daria Nicolodi in a supporting role. Udo Kier, who appeared in Argento's Suspiria, and Coralina Cataldi-Tassoni, who appeared in three of his previous films, both have pivotal roles in the final Mothers chapter.
On 26 June 2009, Giallo premiered at the Edinburgh Film Festival. The following month, he announced that he had started working on a 3D remake of Deep Red, but subsequently this project was shelved due to the commercial failure of Giallo in Italian cinemas. He then announced his decision to write a new screenplay . On 4 March 2011, it was announced that Rutger Hauer had signed on to play Van Helsing in Argento's Dracula 3D, which began shooting in Budapest later in the year. It was released on 19 May 2012 to generally negative reviews.
Italian director Luca Guadagnino helmed Suspiria (2018), a remake of Argento's 1977 film.