Professional wrestling
In 2000, after filming the World Championship Wrestling (WCW) film Ready to Rumble, Arquette was brought into WCW storylines. He made his first appearance on the April 12, 2000, episode of Thunder, sitting in the crowd before leaping into the ring to take part in a worked confrontation with Eric Bischoff and his New Blood stable. Afterwards, he formed an alliance with Chris Kanyon and Diamond Dallas Page, then the reigning WCW World Heavyweight Champion. With their help, he defeated Bischoff in a singles match on the April 24 episode of Nitro. On the following episode of Thunder, Arquette teamed with Page in a match against Bischoff and Jeff Jarrett, with the stipulation that whichever man got the pin would take the championship. Arquette pinned Bischoff again in the match's finish, winning the WCW World Heavyweight Championship in the process.
During his time as champion, Arquette was mostly used as comic relief. He only appeared on two shows as champion, the May 1 Nitro and May 7 Slamboree pay-per-view. During the former, a vignette was shown, filmed on the set of Arquette's film 3000 Miles to Graceland, which also featured his wife Courteney Cox and their co-star Kurt Russell. In the vignette, Cox informs Russell that Arquette is the WCW World Heavyweight Champion, causing Russell to laugh and walk off and Arquette to chase after him with a steel chair. In another portion of the show, Arquette was seen backstage trembling in fear and attempting to "give back" the championship belt. However, he did successfully defend the title against Tank Abbott with help from Page.
Arquette held the title for 12 days until the Slamboree pay-per-view on May 7, 2000, when he was booked to defend the championship against Jarrett and Page in a Triple Cage match, the same match featured in the climax of Ready to Rumble. In the end, he turned on Page and gave the victory to Jarrett. After Slamboree, Arquette cut a promo on the May 8 episode of Nitro, explaining that his entire friendship with Page and title run was a "swerve". Page subsequently ran down to the ring and hit him with a Diamond Cutter. Arquette made one final appearance with WCW at the New Blood Rising pay-per-view on August 13, when he interfered in a match between Buff Bagwell and Kanyon.
Arquette was against the idea of becoming the WCW World Heavyweight Champion, believing that fans like himself would detest a non-wrestler winning the title. Vince Russo, who was the head booker for WCW at the time, insisted that Arquette becoming the champion would be good for the company and for publicity, and Arquette reluctantly agreed to the angle. All the money he made during his WCW tenure was donated to the families of Owen Hart (who died in a freak accident), Brian Pillman (who died from an undiagnosed heart condition), and Darren Drozdov (who became a quadriplegic after an in-ring accident). After the World Wrestling Federation/World Wrestling Entertainment (WWF/WWE) purchased WCW, Arquette's championship run was listed as the top reason for the "failure" of Nitro in a list published by WWE Magazine. Gene Okerlund stated in a 2009 interview on WCW's history that "once Arquette won the title, it might as well been thrown in the trash" due to losing what little credibility it had left at that point, and Arquette's reign as champion has been criticized in other WWE media in the years since, despite the fact that the then-WWF itself briefly booked Vince McMahon as WWF Champion months before Arquette's title win.
On the December 13, 2010, episode of Raw, Arquette made his WWE debut by teaming with Alex Riley in a handicap match against Randy Orton, which they lost.
In 2018, during an interview on The Wendy Williams Show, Arquette said that, in the years following his controversial WCW title win, he had been trolled on the Internet and that he wanted people to have respect for his name in professional wrestling. He began training with professional wrestler Peter Avalon for his return. On July 15, 2018, Arquette made his return to professional wrestling making his debut for Championship Wrestling from Hollywood (CWFH) in a losing effort against RJ City.
On October 6, 2018, Arquette teamed with RJ City to defeat the team of Halal Beefcake (Idris Abraham and Joe Coleman) in a tag team match at Border City Wrestling's 25th Anniversary show in Windsor, Ontario, Canada. The event was filmed by Impact Wrestling to air as a One Night Only pay-per-view in November 2018. On November 16, 2018, Arquette wrestled Nick Gage in a deathmatch at Joey Janela's LA Confidential event. During the match, he suffered a severe cut in the neck, causing him to bleed profusely. After the match, he went to a hospital and was operated on. Arquette later stated that he was done with deathmatches.
On May 23, 2019, Arquette made his debut on Being the Elite, where he attempted to convince Nick and Matt Jackson to allow him to enter the Over the Budget Battle Royal at All Elite Wrestling's (AEW) Double or Nothing event. Neither of them recognized him at first, however they eventually recalled his WCW World Heavyweight Championship reign but still refused to let him compete, instead, giving him a double Superkick.
In June 2021, Arquette announced he was retiring as a wrestler. His last match was on July 31, 2021, as Rob Boss, teaming with A Little Angry Tree defeating Whopper Texas Ranger for Wrestling Pro Wrestling in Burbank, California.
On April 23, 2023, Arquette appeared on AEW's internet television show Hey! (EW).
On January 3, 2026, Arquette made his in ring return for Awesome Championship Wrestling, at their Poughkeepsie Rumble event. He competed in the namesake match, but was quickly eliminated by Richard Holliday.