Marriage and children
He initially planned to marry Mencia de Guzman, daughter of the Duke of Medina Sidonia, but he was forced by King Fernando to marry the king's cousin María de Toledo y Rojas (c. 1490 – May 11, 1549), who secured the transportation and burial of her father-in-law, Christopher Columbus, in Santo Domingo. She was the daughter of Fernando Alvarez de Toledo, 1st Lord of Villoria, son of García Álvarez de Toledo, 1st Duke of Alba, and his first wife María de Rojas, and had the following children:
María Colón de Toledo (c. 1510 – ?), married to Sancho Folch de Cardona, 1st Marquess of Guadalest
Luis Colón, 1st Duke of Veragua (c. 1519/1520/1522 – 1572), married firstly in 1546 to María de Mosquera y Pasamonte, daughter of Juan de Mosquera and his wife Ofrasina de Pasamonte, and had:
María Colón de Toledo y Mosquera, a nun in Valladolid
Felipa Colón de Toledo, 2nd Duchess of Veragua. He married secondly in Valladolid, on 19 October 1555, to Ana de Castro Osorio, daughter of Beatriz de Castro Osório, 6th Countess of Lemos and Sárria, and her second husband Alvaro Osorio, without issue.
Cristóbal Colón de Toledo (c. 1510 – 1571), married firstly to María Leonor Lerma de Zuazo, without issue; married secondly to Ana de Pravia, and had one son (Diego Colon y Pravia [c. 1551 – Jan 27, 1578]) and one daughter (Francisca Colon y Pravia, [c. 1552 - April 1616]; and married thirdly to María Magadalena de Guzmán y Anaya, and had:
Diego Colón de Toledo, father of Diego the 4th Admiral of the Indies.
Francisca Colón de Toledo y Pravia (c. 1550 – April, 1616), married Diego de Ortegón (c. 1550 –), and had four children: Guiomar de Ortegon y Colon [d. 1621]; Jacoba de Oretgon y Colon [d. 1618]; Ana de Ortegon y Colon; and Josefa de Ortegon y Colon
María Colón de Toledo y Guzmán (c. 1550 – ?), married to Luis de Avila, and had:
Cristóbal de Avila y Colón (1579–?), unmarried and without issue
Luis de Avila y Colón (1582–1633), married Maria de Rojas-Guzman Grajeda, without issue; married secondly to Francisca de Sandoval and had one son Cristobal
Bernardino Dávila y Colón (d. 1633)
Maria de Avila y Colón (1592–?), married Alonso de Guzman Grajeda and had one daughter (Mayor de Grajeda y Avila [c.1611-])
Magdalena Dávila Colón (1592–1621)
María Dávila Colón (1596–?)
Juana Colón de Toledo (died c. 1592), married her cousin Luis de La Cueva y Toledo; their only child was María Colón de la Cueva (c. 1548 – c. 1600) who claimed the duchy of Veragua and died in New Spain (México).
Isabel Colón de Toledo (c. 1515 – ?), married Don Jorge Alberto de Portugal y Melo (1470–?), 1st Count of Gelves (who married secondly; his first marriage to Dona Guiomar de Ataíde remained childless), son of Don Álvaro de Bragança, Lord of Tentúgal, Póvoa, Buarcos and Cadaval and Chancellor-Major of the Realm of Portugal. Their grandson, D. Nuno Álvares Pereira Colón y Portugal, Duke of Veragua and Admiral of the Indies, became regent of the Kingdom of Portugal from 1621 until his death.
