Original series
The network was known early on for its daily video simulcast of the Howard Stern Show, which aired from June 20, 1994, until July 8, 2005, weeknights in a truncated half-hour form, airing three times in late night. The program was discontinued several months after Stern moved to Sirius Satellite Radio and sold the video rights to his show to pay-per-view provider In Demand as a monthly pay offering (video rights are now held by SiriusXM).
E! is known for its live red carpet pre-shows for the industry's three prominent award shows, the Primetime Emmy Awards, the Golden Globe Awards, and the Academy Awards, and were famous for their fashion critiques by Joan Rivers; Rivers also hosted post-awards specials under the title Fashion Police, which became a regular weekly series in September 2010. In April 2017, it was announced that E! had acquired the People's Choice Awards, which will move to the network from CBS in 2018 with a new November scheduling. The network promoted that the show would be given an "end-to-end" experience that will leverage its existing experience in awards show coverage. As ratings declined across all of cable television overall, the People's Choice returned to broadcast television in 2021, with E! simulcasting the ceremony with NBC.
The network also produces many documentary and biographical series, most notably E! True Hollywood Story; many of E!'s original specials are entertainment-related ranging from light fare (such as 25 Cutest Child Stars All Grown Up) to serious fare (such as 15 Most Unforgettable Hollywood Tragedies). It also produces specials centering on investigative and crime stories including E! Investigates, which features topical investigative reports on subjects ranging from child prostitution to teenage pregnancy.
In recent years, the network has become known for its reality television programs. Its most popular series for over a decade has been Keeping Up with the Kardashians, which spawned eight spin-off series and countless specials. Other original reality programming airing on the network currently includes Total Divas–a series featuring the WWE's Bella Twins, Hollywood Medium with Tyler Henry, the plastic surgery repair series Dr. 90210 and Botched, along with Very Cavallari with Kristin Cavallari and her (later ex-) husband Jay Cutler, Ladygang–a television version of the popular podcast, and dating show Dating #NoFilter,
E! has had five comedy programs: the late night talk show Chelsea Lately, hosted by comedian Chelsea Handler, its scripted/improvised spin-off After Lately, and The Soup (based on the popular 1991–2002 E! series Talk Soup), featuring clips of the previous week's TV shows with humorous commentary delivered by the host, actor/comedian Joel McHale. Handler also produced Love You, Mean It, a weekly comedic look at pop culture hosted by Whitney Cummings, and a nightly talk show from actress Busy Philipps, Busy Tonight. The Soup returned in February 2020, with new host Jade Catta-Preta, though it, and many of E!'s in-studio shows, were cancelled in the last quarter of 2020 due to the effects of the COVID-19 pandemic hampering production.
On September 8, 2020, it was announced the network's most popular series Keeping Up with the Kardashians would be ending with season 20 in 2021.