Gilles is a surname. Notable people with the surname include:
Alexe Gilles (born 1992), American figure skater, sister of Piper and Todd Gilles
Eve Gilles (born 2003), French model, beauty pageant titleholder, and Miss France 2024
Herbert Michael Gilles (1921–2015), British-Maltese physician and professor of tropical medicine
Jean Gilles (composer) (1668–1705), French composer
Jean Gilles (French Army officer) (1904–1961), French general
Osmond Gilles (1788–1866), settler, pastoralist, mine owner and first colonial treasurer of South Australia
Piper Gilles (born 1992), American figure skater, sister of Alexe and Todd Gilles
Ralph Gilles (born 1970), American automobile designer and executive at Stellantis
Todd Gilles (born 1986), American figure skater, brother of Alexe and Piper Gilles
Werner Gilles (1894–1961), German painter