The surname Grande or Del Grande is a surname of Spanish or Italian origin and may refer to:
Andrés Grande (born 1976), Argentine former footballer
Ariana Grande (born 1993), American singer, songwriter and actress
Facón Grande (1883–1921), Argentine worker and syndicalist
Frankie Grande (born 1983), American actor, singer, dancer, television personality and half-brother of Ariana Grande
George Grande, American sportscaster who hosted the very first broadcast of SportsCenter on ESPN in 1979
Hilde Grande (born 1975), Norwegian politician
Johnny Grande (born John A. Grande, 1930–2006), member of Bill Haley's backing band, The Comets
Lance Grande (born 1951), American evolutionary biologist
Louis Del Grande (born 1943), Canadian television writer and actor
Matías Grande (born 2004), Mexican archer
Mike Del Grande (born 1953), Canadian politician
Rita Grande (born 1975), Italian professional tennis player
Rutilio Grande (1928–1977), Salvadoran Jesuit priest
Sandro Grande (born 1977), Canadian soccer player
Sean Grande (born 1969), American television and radio sportscaster
Sidney Grande (1927–2016), American football coach
Svante Grände (1947–1975), Swedish aid worker and guerrilla fighter in Latin America during the 1970s.
Toni Grande (born 1947), retired Spanish football player
Tony Grande (1943–2006), politician in Ontario, Canada
Xavi Grande (born 2005), Spanish footballer
Stage names
João Grande (born João Oliveira dos Santos, 1933), Grão-Mestre of the Afro-Brazilian martial art of capoeira Angola
Jono El Grande (born Jon Andreas Håtun, 1973), autodidactic Norwegian composer, band leader, guitarist and conductor