Harwell is a surname. Notable people with the surname include:
Beth Harwell (born 1957), American politician
Corey Harwell, American neuroscientist
David W. Harwell (1932–2015), American judge
Ernie Harwell (1918–2010), American sportscaster
Isiah Harwell (born 2007), American basketball player
Jack Harwell, American sheriff
Mason Harwell (1806–1879), American slave trader
Robert Bryan Harwell (born 1959), American judge
Steve Harwell (1967–2023), American singer and musician