Heflin is a surname. Notable people with the surname include:
Clarence Heflin (1921–2007), American politician from Missouri
Donald Heflin (born 1958), American diplomat and ambassador
Frances Heflin (1920–1994), American actress
Howell Heflin (1921–2005), American politician from Alabama
Jack Heflin (born 1998), American football player
James Thomas Heflin (1869–1951), American politician from Alabama
Milt Heflin (born 1943), NASA's first Chief Flight Director
Van Heflin (1910–1971), American actor
Victor Heflin (born 1960), American football player