Hisamoto (written: 久本) is a Japanese surname. Notable people with the surname include:
Masami Hisamoto (久本 雅美; born 1958), Japanese comedian, actress and singer
Yuichi Hisamoto (久本 祐一; born 1979), Japanese baseball player
Ricardo Hisamoto (久本リカルド ; born 1967), Japanese-Brazilian Biologist
Hisamoto (written: 久元 or 尚基) is also a masculine Japanese given name. Notable people with the name include:
Hijikata Hisamoto (土方 久元; 1833–1918), Japanese politician
Nijō Hisamoto (二条 尚基; 1471–1497), Japanese kugyō