Political career
In 1982, at the age of 26, Méndez de Vigo was appointed director of interparliamentary relations for the Cortes Generales. In 1984 he accepted the position of special advisor to then-secretary general of the Council of Europe, Marcelino Oreja.
He joined the People's Party at its founding Conference in 1989, and stood unsuccessfully in that year as one of its candidates at the European election.
In October 1992 he was elected a Member of the European Parliament, a position he held until December 2011. He also served as a member of the People's Party's National Steering Committee.
Méndez de Vigo served as the European People's Party co-ordinator on the Committee on Constitutional Affairs from 1994 and on its Committee on Economic and Monetary Affairs (2009–2011), as well as:
Chairman of the EP Delegation to the Convention drafting the Charter of Fundamental Rights (1999–2000);
Chairman of the EP Delegation to the European Convention (2003–04);
EP representative to the IGC (2004);
Parliament's rapporteur (with Richard Corbett MEP) on the Treaty establishing a European Constitution (2004);
Parliament's rapporteur (with Richard Corbett MEP) on the Treaty of Lisbon.
Between 2006 and 2007, Méndez de Vigo served as member of the Amato Group, a group of high-level European politicians unofficially working on rewriting the Treaty establishing a Constitution for Europe into what became known as the Treaty of Lisbon following its rejection by French and Dutch voters. In 2009 he was appointed president of the College of Europe.
In December 2011 he joined Mariano Rajoy's first government as Secretary of State for the European Union. In June 2015 he was appointed Minister of Education, Culture and Sport in replacement of José Ignacio Wert. In November 2016, in the Second Rajoy Government, he was also appointed Spokesperson of the Government.
In March 2019 he left active politics.