Jadwiga Wypyska (née Łuszkowska; about 1616 in Lviv – after 20 May 1648 in Merkinė) was a Polish noblewoman, known as the mistress of Polish king Ladislaus IV Vasa.
She was the daughter of merchant Jan Łuszkowski (died 1627) and Anna (died after 1635).
She had a son, Władysław Konstanty Vasa, in 1635, and an unknown daughter, the next year.
In 1637, she married Jan Wypyski, starost of Merkinė (died before 18 December 1647).