Career
At the age of nine, she became a newscaster for RPN 9's NewsWatch Kids Edition. She got her biggest break from the same channel when she got the lead role in the soap opera Flordeluna a TV soap where she played Flor from 1979 until 1984, when she momentarily quit showbiz to continue her studies. The soap continued to air a few more years after Janice left but it started going on a downward trend and never regained its popularity.
De Belen returned to showbiz, returning to TV with the soap Jesy and the early evening variety show The Big, Big Show. She was considered the "80s Teen Drama Princess" alongside Julie Vega, whose soap Anna Liza provided stiff competition to Flordeluna. In the 1980s, de Belen and Vega co-starred in a number films, mostly produced by Regal Films. In 1982, de Belen was partnered with Gabby Concepcion through the films Puppy Love and Home Sweet Home.
She returned to the world of TV in soap in 1985 with Andrea Amor and Don Camote dela Mancha, both aired on GMA 7. Her transformation from a teenage star to a serious actress started in 1989 when she topbilled Mina Films' Rosenda opposite erstwhile boyfriend Gabby Concepcion. She received her first Best Actress, the Raha Sulayman Award, recognition in 1991 for Vision Films' Kailan Ka Magiging Akin, a Manila Film Festival entry.
In 2001–2010, after her separation from husband John Estrada, she hosted the morning talk show SiS also on GMA-7 with sister Gelli de Belen and their friend Carmina Villarroel.
In 2010, de Belen was one of those names have been inducted into the Eastwood City Walk of Fame.
In 2011–2012, she starred in the TV series Budoy. She followed it up with performance in the television series Ina, Kapatid, Anak which aired on the Primetime Bida Block and worldwide through TFC from 2012 to 2013.
She co-hosted Showbiz Inside Report as well from February 2012 to October 2013 and until recently, was also doing Buzz ng Bayan with Boy Abunda.
In 2016, she moved back to GMA to appear in Destined to Be Yours and My Korean Jagiya.
In 2018, she returned to ABS-CBN and was cast in The General's Daughter and Sino ang Maysala?: Mea Culpa, various episodes of Maalaala Mo Kaya, La Vida Lena, Love in 40 Days and Dirty Linen.