2007–2019: The Big Bang Theory and theatre roles
Parsons has estimated that he auditioned for between 15 and 30 television pilots, but on many of the occasions when he was cast, the show failed to find a television network willing to purchase it. The exception came with The Big Bang Theory. After reading the pilot script, Parsons felt that the role of Sheldon Cooper would be a very good fit for him. Although he did not feel any sort of relationship with the character, he was enchanted by the dialogue structure, the way the writers "brilliantly use those words that most of us don't recognize to create that rhythm, and the rhythm got me. It was the chance to dance through that dialogue and in a lot of ways still is." In his audition, Parsons impressed series creator Chuck Lorre, who insisted on a second audition to see if Parsons could replicate the performance. Parsons was cast as Sheldon Cooper, a physicist with social apathy who frequently belittles his friends. The role required Parsons to "rattle off line after line of tightly composed, rhythmic dialogue, as well as then do something with his face or body during the silence that follows." Parsons credits his University of San Diego training with giving him the tools to break down Sheldon's lines.
Television critic Andrew Dansby compares Parsons's physical comedy to that of Buster Keaton and other silent film stars. Lorre praises Parsons' instincts, saying that "You can't teach that." Lorre describes Parsons' "great sense of control over every part of his body, the way he walks, holds his hands, cocks his head, the facial tics as 'inspired'." Reviewer Lewis Beale describes Parsons' performance as "so spot-on, it seems as if the character and the actor are the same person." Parsons admits that the work is "more effort than I ever thought a sitcom would take, and that's really the fun of it." In August 2009, Parsons won the Television Critics Association award for individual achievement in comedy, beating Alec Baldwin, Tina Fey, Steve Carell, and Neil Patrick Harris. Parsons was nominated for Primetime Emmy Awards in 2009, 2010, 2011, 2012, 2013 and 2014 for Outstanding Lead Actor in a Comedy Series, winning in 2010, 2011, 2013 and 2014. In September 2010, Parsons and co-stars Johnny Galecki and Kaley Cuoco signed new contracts, guaranteeing each of them $200,000 per episode for the fourth season of The Big Bang Theory, with substantial raises for each of the next three seasons. The three were also promised a percentage of the show's earnings. In January 2011, Parsons won the Golden Globe award for Best Actor in a Television Series – Comedy. From August 2013, Parsons, Cuoco and Galecki each earned $325,000 per episode. In August 2014, Parsons, Galecki and Cuoco once again signed new contracts, guaranteeing each of them $1 million per episode for the eighth, ninth, and tenth seasons of The Big Bang Theory, as well as quadrupling their percentage of the show's earnings to over 1% each.
In 2011, Parsons appeared with Jack Black, Owen Wilson, Steve Martin, and Rashida Jones in the comedy film The Big Year. It was released in October. That same year, he appeared as the human alter ego of Walter, the newest Muppet introduced in The Muppets. On May 18, 2012, Parsons began appearing on Broadway as Elwood P. Dowd in a revival of Harvey. He reprised the role in The Normal Heart (2014), and he received his seventh Emmy nomination, this time in the category of Outstanding Supporting Actor in a Miniseries or Movie. Parsons received a star on the Hollywood Walk of Fame on March 11, 2015. He voiced Oh, one of the lead roles in the DreamWorks Animation comedy film Home (2015), alongside Rihanna.
Parsons and Todd Spiewak founded That's Wonderful Productions in 2015 with the intention of raising distinct voices and producing work with an underlying sense of purpose and social consciousness. Their work includes Special, Equal, Call Me Kat and A Kid Like Jake. Parsons and Spiewak are also Executive Producers of Young Sheldon. On January 29, 2015, it was announced that Parsons would star as God in the Broadway production of An Act of God, a new play by David Javerbaum and directed by Joe Mantello. The play began previews at Studio 54 on May 5, 2015 and closed August 2, 2015, to positive reviews. In 2016, Jim Parsons played a supporting role as STG (special task group) head engineer Paul Stafford in the biographical drama film Hidden Figures. The film was directed by Theodore Melfi, who had previously worked with Parsons in commercials for Intel.
In 2017, Parsons started hosting his own SiriusXM talk show, Jim Parsons Is Too Stupid for Politics. The show ran for six weeks. In August 2018, Parsons announced his refusal of a contract worth $50 million for seasons 13 and 14 of The Big Bang Theory. The producers simultaneously announced that, after 279 episodes, the most of any multi-camera series in TV history, the show would come to an "epic, creative close" in May 2019. Parsons was expected to remain in his role as narrator of the prequel series, Young Sheldon. In 2018, Parsons was one of the actors who voiced the audiobook A Day in the Life of Marlon Bundo. Parsons starred as party host Michael in the 50th anniversary Broadway production of The Boys in the Band, which won the 2019 Tony Award for Best Revival of a Play, reprising his performance (with the whole Broadway anniversary cast) in the 2020 film adaptation.