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John Coffin

virologist

John Coffin

American virologist

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About John Coffin

John Coffin is an American virologist. Born in Boston, Massachusetts, raised in Schenectady, New York, Coffin is a professor of Molecular Biology and Microbiology at Tufts University in Boston. He is also the former director of the HIV Dynamics and Replication Program of the National Cancer Institute (NCI) and serves as special advisor to the director of the Center for Cancer Research at NCI. He is a member of the National Academy of Sciences and a recipient of American Cancer Society professorship. He has advised policy committees at the national level regarding retrovirus-related matters. Coffin was programme committee chair for the 18th Conference on Retroviruses and Opportunistic Infections in 2011.

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Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction Multiple, linked human immunodeficiency virus type 1 drug resistance mutations in treatment-experienced patients are missed by standard genotype analysis Depletion of latent HIV-1 infection in vivo: a proof-of-concept study Flexible Use of Nuclear Import Pathways by HIV-1 Tufts University Wesleyan University

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