Acting career
Nettles played Laertes to Tom Courtenay's Hamlet in 1969 at the University Theatre for 69 Theatre Company in Manchester. From 1969 to 1970, he was in repertory at the Northcott Theatre in Exeter, and in the latter year had his first screen role in the film One More Time. The following year, he played Dr. Ian Mackenzie in the period drama A Family at War, a role he continued until 1972. Following that, he had small parts in many TV programmes including The Liver Birds, Dickens of London, Robin of Sherwood and an episode of Enemy at the Door called "Officers of the Law", first broadcast in March 1978. The latter was set in Guernsey during the German occupation of the Channel Islands in the Second World War, and Nettles played a police detective ordered to work for the Germans, who is anguished over the conflict between his duty and collaborating with the enemy.
In 1981, Nettles became a household name in the UK when Robert Banks Stewart cast him as States of Jersey Police officer Jim Bergerac in the crime drama Bergerac. The series ran for 87 episodes on BBC1 until 1991. Following the end of Bergerac, Nettles did five seasons with the Royal Shakespeare Company, appearing in The Winter's Tale, The Merry Wives of Windsor, Julius Caesar, Richard III and The Devil Is an Ass. In 1992 he appeared in an episode of Boon, and in 1993 reprised the role of Jim Bergerac in a guest appearance in the spoof police comedy The Detectives.
In 1995, Nettles was approached by Brian True-May to play Tom Barnaby in a new murder mystery series he was to produce called Midsomer Murders. This was to be the second major role of his television career, again playing a police detective. Midsomer Murders was an immediate hit, achieving 13.5 million viewers on its launch in 1997 and was sold to more than 200 countries worldwide. In 2001 Nettles guest-starred in an episode of Heartbeat playing fraudster Giles Sutton. In 2003, he played Barnaby in the Boxing Day episode of French & Saunders. In 2007 he appeared in the BBC Radio 4 comedy series Will Smith Presents the Tao of Bergerac, alongside comedian Will Smith, which was about an obsessive fan of the series.
In February 2009, it was announced that Nettles had decided to leave Midsomer Murders after two further series were made. His final appearance on-screen was on 2 February 2011, by which time he had appeared in 81 episodes. About his departure, he commented, "It's always wise to leave people wanting more, rather than be booed off the stage because you bored them."
In 2016 and 2017, Nettles had a recurring role as Ray Penvenen in the second and third series of the historical drama Poldark.
He later retired from acting, although he would still provide voice work on television. He turned down the offer for a cameo appearance in the 2025 reboot of Bergerac.