Marriages and issue
Thynne married twice:
Firstly, in 1549, to Christiana Gresham, a daughter of Sir Richard Gresham and a sister of Sir Thomas Gresham, founder of the Royal Exchange. Their marriage settlement was signed in January 1549. By Christiana Gresham he had three sons and six daughters, including:
John Thynne (died 1604), eldest son and heir. He was knighted by King James I on 11 May 1603, four days after James arrived to take up the English crown. He married Joan Hayward, a daughter of Sir Rowland Hayward, twice Lord Mayor of London by his wife Joan Tyllsworth, daughter and heiress of Sir William Tyllsworth. Joan Hayward brought the Thynne family new estates in Shropshire and elsewhere.
Dorothy Thynne (buried 25 September 1592), wife of Sir John Strangways (c.1548-1593) of Melbury House, Melbury Sampford, Somerset, and of Abbotsbury in Dorset, Sheriff of Dorset. Their third son and eventual heir was Sir John Strangways (1585–1666), MP.
Anne Thynne, wife of John Cole;
Francis Thynne, who married Alice Knocker;
Thomas Thynne, who married Emily Bembridge;
Elizabeth Thynne, wife of John Chamberlayne;
Catherine Thynne, who married firstly Walter Long (1565–1610) and secondly Sir Edward Fox of Gwernigo, Mongomery, Wales.
Frances Thynne;
Maria Thynne.
Secondly, in about 1566, after the death of his first wife, he married Dorothy Wroughton, a daughter of Sir William Wroughton, of Broad Hinton, by his wife Eleanor Lewknor. She survived her husband and married secondly Carew Raleigh of Downton House near Salisbury, a member of parliament for Downton in 1604, and the brother of Sir Walter Raleigh. By Dorothy Wroughton he had a further five sons:
Egremont Thynne, who married Barbara Calthorpe;
Henry Thynne, who married Elizabeth Chudleigh;
Charles Thynne;
Edward Thynne, who married Theodosia Manners;
William Thynne, who married Alice Talbot.