Modeling
In 2002, Mizuhara participated in a contest and won an audition for fashion magazine Seventeen. At the audition, she was picked as Miss Seventeen and became an exclusive model for Seventeen for the next three years. At age 16, she moved to Tokyo alone, living separately from her mother and sister in Kobe to advance her career in modeling. In July 2007, Kiko Mizuhara became an exclusive model for fashion magazine ViVi.
Starting 2008 Kiko Mizuhara has been a regular runway model at the Tokyo Girls Collection. Her international runway debut was at The Paris Collections in Olympia Le Tan's Spring/Summer 2014 Show. In the same year, Mizuhara was invited by British Fashion Designer Nasir Mazhar to walk for his S/S 2014 Collection at London Fashion Week and at Fashion Designer Jeremy Scott debut show for Moschino in Milan Fashion Week. Mizuhara was chosen to open and close the Fall/Winter 2014 Show of Sretsis, a Thai-brand clothing line, during the Mercedes-Benz Fashion Week in Tokyo. She has also participated in Nicola Formichetti's first full collection show for Diesel in Venice, Italy. In 2017, Kiko Mizuhara walked for Alexander Wang (designer) S/S 2018 Ready-to-Wear collection at New York Fashion Week.
Aside from her runway experiences, Mizuhara has graced numerous magazine covers and features not only in Japan but also in Asia and Europe. She has appeared in major Vogue editorials for Vogue Japan, Vogue China, Vogue Taiwan, Vogue Italia, American Vogue, Vogue Girl Japan and L'Uomo Vogue. She has done covers and spreads for Nylon, Numero, Vivi, Seventeen, Grazia, GQ, Elle, Harper's Bazaar, L'Officiel, Maquia Gisele, V Magazine, Another Magazine, Dazed and Confused, Cosmopolitan, Dedicate Magazine, and Jalouse Magazine. Mizuhara has also shot ad campaigns for Diesel, Phillip Lim, Vivienne Tam, Reebok, Kitsuné, Tiffany & Co., Shiseido, etc. She was appointed as a Chanel ambassador. In 2012, Mizuhara was photographed by Karl Lagerfeld for Chanel's The Little Black Jacket campaign. In December 2013, Mizuhara participated in the Chanel Metiers d'Art Show in Dallas, Texas.
Mizuhara starred in the Marc Jacobs Eyewear 2017 ad campaign. In 2018, she was appointed as the first Asian ambassador for Dior. She was also welcomed into the Coach family in the same year.