2017–2021: International appearances and Antares
Wu made his runway debut at Burberry's Fall 2016 Men's Show in London. He also took part in the 2016 NBA All-Star Game as a member of Team Canada, coached by Drake.
In January 2017, Wu made his Hollywood film debut in D. J. Caruso's XXX: Return of Xander Cage. He released the single "Juice", featuring Vin Diesel in the music video, as part of the soundtrack on January 19. Wu then starred in Stephen Chow's film, Journey to the West: The Demons Strike Back, playing Tang Sanzang.
In February 2017, Wu represented China at the 59th Annual Grammy Awards ceremony in Los Angeles. The same month, Wu accepted his second invitation to play in the 2017 NBA All-Star Game in New Orleans. Forbes listed Wu their 30 Under 30 Asia 2017 list which comprises 30 influential people under 30 years old who have made substantial effect in their fields.
In July 2017, Wu appeared in Luc Besson's science fiction film Valerian and the City of a Thousand Planets.
In October 2017, Wu released "Deserve", featuring American rapper Travis Scott. Upon its release, "Deserve" placed No. 1 on the U.S. iTunes chart, making Wu the only Chinese artist to achieve the feat. At the end of 2017, Wu released a single, "B.M.". Kris released another single, "Miss You" featuring Zhao Liying on Christmas Day 2017. The music video was released on December 28.
Wu starred in the 2018 Hong Kong-made action thriller Europe Raiders, alongside Tony Leung.
As of April 2018, future music from Wu will be released internationally, excluding Japan and Korea, through a partnership of Universal Music China, Interscope in the United States and Island Records in the United Kingdom Wu's debut album Antares featuring the 2018 singles "Like That" and "Freedom" (featuring Jhené Aiko) was released on November 2, 2018.
On April 19, 2019, Wu released a single, "Big Bowl, Thick Noodle", the music video for which was viewed over 90 million times on streaming site Miaopai. Wu then embarked on his Alive Tour, performing at cities across China. On November 6, 2019, his 29th birthday, Wu released a second single, "Eternal Love", along with an accompanying micro film starring himself and Japanese model Kōki.
On April 22, 2020, Wu released the four-track EP Testing, preceded by the single "Aurora" on April 15. The EP was pre-ordered one million times just 87 minutes after being made available on Tencent streaming platform QQ Music, marking a new record for the platform. The EP features three Chinese songs and one in English.