La Serena [la seˈɾena] is a comarca located in the east of the province of Badajoz, Extremadura, Spain. The main town is Castuera.
It is a comarca based on a natural region which includes plains, as well as some low ranges of the Sierra Morena. The climate is continental, with strong fluctuations.
The area's pastures are grazed by merino sheep, which are raised for wool and for milk used to make La Serena cheese, a product with a protected product by its origin status.
The population of the territory is around 39,000 inhabitants.
Municipalities
The comarca contains the following municipalities: