Lobo is a surname found in the Galician, Spanish and Portuguese languages meaning "wolf", and in other languages with other meanings. Notable people with the surname include:
Almiro Lobo (born 1982), known as Miro, Mozambican football player
Alonso Lobo (1555–1617), Spanish composer
Amberley Lobo (born 1990), Australian television presenter
Anthony Theodore Lobo (1937–2013), Pakistani Catholic bishop
António Lobo de Almada Negreiros (1868–1939), Portuguese journalist, colonialist writer, essayist and poet
António Lobo Antunes (1942–2026), Portuguese writer and psychiatrist
Baltasar Lobo (1910–1993), Spanish artist, anarchist and sculptor
Bruno Lobo (born 1993), Brazilian kite surfer
Cavin Lobo (born 1988), Indian footballer
Claude Lobo (1943–2011), French car designer
Cristiana Lôbo (1957–2021), Brazilian journalist
Cristiana Lobo (swimmer) (born 1972), Brazilian swimmer
Duarte Lobo (1565–1646), Portuguese composer
Edu Lobo (born 1943), Brazilian singer, guitarist, and composer
Emerico Lobo de Mesquita (1746–1805), Brazilian composer, music teacher, conductor and organist
Emiro Lobo (1948–2007), Venezuelan painter, graphic artist and designer
Erik Lobo (born 1970), American artist and comedic actor
Eugenio Gerardo Lobo (1679–1750), Spanish soldier and poet
Francisco Miranda da Costa Lobo (1864–1945), Portuguese astronomer, pioneer of spectrography
Francisco Rodrigues Lobo (1580–1622), Portuguese poet and bucolic writer
Ignatius P. Lobo (1919–2010), Indian Catholic prelate
Ildo Lobo (1953–2004), Cape Verdean singer
Jason Lobo (born 1969), British athlete
Jerónimo Lobo (1593–1678), Portuguese Jesuit missionary
João Lobo Antunes (1944–2016), Portuguese neurosurgeon
Julio Lobo (1898–1983), Cuban sugar trader and financier
Leonard D. Lobo, Indian headmaster
Luis Lobo (born 1970), Argentine tennis player
Manuel Lobo Antunes (born 1958), Portuguese lawyer and diplomat
Mario Humberto Lobo (born 1964), Argentine footballer
Mary Kay Lobo (born 1975), American psychiatric neuroscientist
Mervyn Lobo, Pakistani health activist
Michael Lobo (born 1953), Indian scientist and genealogist
Michael Lobo (politician) (born 1976), Indian politician
Nahuel Lobo (born 1991), Argentine rugby player
Pedro Lobo (born 1954), Brazilian photographer
Porfirio Lobo Sosa (born 1947), President of Honduras
Rebecca Lobo (born 1973), American basketball player and television analyst
Ricardo Lobo (born 1984), Brazilian football player
Rogerio Hyndman Lobo (1923–2015), Macanese businessman
Rogerio Lobo (boxer) (1971–2006), Brazilian boxer
Sascha Lobo (born 1975), German blogger, writer, journalist and copywriter
Stephen Lobo (born 1973), Canadian actor
Tatiana Lobo (1939–2023), Chilean-born Costa Rican writer