Thomas was first heard on radio delivering talks about his travels in 1929 and 1930: for example, he spoke on the NBC Radio Network in late July 1930 about his trip to Cuba. Then, in late September 1930, he took over as the host of the Sunday evening Literary Digest program, replacing the previous host, Floyd Gibbons. On the program, he told stories of his travels. The show was fifteen-minutes long, and heard on the NBC Network. Thomas soon changed the focus of the program from his own travels to interesting stories about other people. By October 1930, he was including more news stories. It was at this point that the program, which was now on six days a week, moved to the CBS Radio network.
After two years, he switched back to the NBC Radio network but returned to CBS in 1947. He was not an employee of either NBC or CBS, contrary to today's practices, but was employed by the broadcast's sponsor Sunoco. He returned to CBS to take advantage of lower capital-gains tax rates, establishing an independent company to produce the broadcast which he sold to CBS, like coverage of the Coronation Ice Show in Lake Placid, New York in 1934. He hosted the first television news broadcast in 1939 and the first regularly scheduled television news broadcast beginning on February 21, 1940, over W2XBS (now WNBC) New York, which was a camera simulcast of his radio broadcast.
In the summer of 1940, Thomas anchored a television broadcast of the 1940 Republican National Convention, the first live telecast of a political convention, which was fed from Philadelphia to W2XBS and on to W2XB Schenectady (now WRGB). He was not actually in Philadelphia but was anchoring the broadcast from a New York studio and merely identifying speakers who addressed the convention to the few thousand people who had television sets in those three cities.
In April 1945, Thomas flew in a normally single-person P-51 Mustang over Berlin while it was being attacked by the Soviet Union, reporting live via radio.
In 1953, Thomas was featured in The Ford 50th Anniversary Show that was broadcast simultaneously on the NBC and CBS television networks. The program was viewed by 60 million persons. Thomas presented a tribute to the classic days of radio.
His persistent debt problems were remedied by Thomas' manager/investing partner, Frank Smith who, in 1954, became the President of co-owned Hudson Valley Broadcasting Company, which, in 1957, became Capital Cities Television Corporation.
The television news simulcast was a short-lived venture for Thomas, as he favored radio. It was over radio that he presented and commented upon the news for four decades until his retirement in 1976, the longest radio career of anyone in his day, since surpassed by Paul Harvey. His signature sign-on was "Good evening, everybody" and his sign-off was "So long, until tomorrow," phrases that he used as titles for his two volumes of memoirs. After his nightly CBS radio news program ended its run on May 14, 1976, he hosted Lowell Thomas Remembers, a 39-week series produced by the South Carolina Educational Television Network which aired on PBS in 1976 and 1977. It featured Fox Movietone newsreels from the 1920s to the 1950s, with the half-hour installments covering each of the years in that four-decade span.