Manes, Mánes or Mánes is a surname. Notable people with the surname include:
Antonín Mánes (1784–1843), Czech painter
Donald R. Manes (1934–1986), borough president of Queens, New York
Édouard Manès (1835–1898), governor general of French India
Facundo Manes (born 1969), Argentine neurologist and politician
Franco Manes (born 1963), Italian politician
Gina Manès (1893–1989), French film actress
Josef Mánes (1820–1871), Czech painter
Michelle Manes, American mathematician
Pablo Curatella Manes (1891–1963), Argentine painter
Quido Mánes (1828–1880), Czech painter