Marcellino is an Italian surname. Notable people with the surname include:
Carl L. Marcellino (born 1942), member of the New York State Senate
Dennis Marcellino (born 1948), American musician, speaker and author of psychology, philosophy, theology and political books
Fred Marcellino (1939–2001), American illustrator and later an author of children's books
Jocko Marcellino (born 1950), American singer, musician, songwriter, producer and actor, one of the founders of Sha Na Na
Muzzy Marcellino (1912–1997), American singer and musician, known primarily for his clear, melodious style of whistling
Noella Marcellino, (born 1951), American Benedictine nun who has earned a doctorate in microbiology from the University of Connecticut
P.J. Marcellino (born 1978), Portuguese-Canadian filmmaker
Raffaele Marcellino (born 1964), Australian composer