Mayor Guillén de Guzmán (1205–1262) was a member of one of the most aristocratic families in the court of King Ferdinand III of Castile. Her parents were Guillén Pérez de Guzmán and María González Girón, daughter of Gonzalo Rodríguez Girón and his first wife Sancha Rodríguez, and sister of Pedro Rodríguez de Guzmán, Castile's first adelantado and father of Alonso Pérez de Guzmán.
- Position held
- royal mistress
- Citizenship
- Crown of Castile
- Born
- 1205
- Died
- 1262