2010–present
In 2010, Enos was cast in her first lead role in a television series: Detective Sarah Linden in the AMC drama series The Killing, based on the Danish television series Forbrydelsen. For her role as Linden, Enos received nominations for an Primetime Emmy Award for Outstanding Lead Actress in a Drama Series, Golden Globe Award for Best Actress – Television Series Drama, and three Saturn Award for Best Actress on Television. The series ran for four seasons, ending in 2014.
Following her breakout role in The Killing, Enos began her career in feature films. She played Karin Lane, the wife of Brad Pitt's character in World War Z (2013). Also in 2013, she co-starred as Josh Brolin's character's wife in Gangster Squad, and appeared opposite Reese Witherspoon in the crime drama Devil's Knot, based on a true story, the West Memphis Three. In 2014, she appeared in the crime thriller Sabotage directed by David Ayer and later starred in drama film If I Stay directed by R. J. Cutler, based on the novel of the same name by Gayle Forman.
Enos co-starred later that year alongside Ryan Reynolds in The Captive, directed by Atom Egoyan. Enos was cast as lead actress in the thriller Never Here, which was directed by Camille Thoman.
In March 2015, it was announced that Enos had been cast as the lead character in the ABC legal drama series, The Catch, produced by Shonda Rhimes. She starred as the lead character Alice Vaughan, the head of a high-end private detective agency. The Catch aired its first 10-episode season in spring 2016, and a second 10-episode season in 2017 as part of ABC's "TGIT" Thursday night lineup.
Also in March 2015, it was announced Enos would star alongside Olivia Cooke in Katie Says Goodbye, an independent film. That same year, she starred in Behold My Heart, directed by Joshua Leonard.
In 2019, she appeared as Marissa Wiegler in the action drama streaming television series Hanna on Amazon Prime Video. The series is based on the 2011 film of the same name, with Cate Blanchett originating the role of Wiegler.
In August 2020, it was announced the 2018 film The Lie (her reunion with The Killing's showrunner Veena Sud) would be included in Amazon Prime Video's Welcome to the Blumhouse horror film anthology. It was released in the anthology's first installment on October 6, 2020.
