Mole and de Mole are surnames. Notable people with these surnames include:
Mole
Arthur Mole (1889–1983), British-born American WW1 commercial photographer
Charles Mole (1886–1962), British architect
Chris Mole (born 1958), UK Labour Member of Parliament
Fenton Mole (1925–2017), American baseball player
Jamie Mole (born 1988), English professional footballer
Louis-Mathieu Molé (1781–1855), French statesman
Miff Mole (1898–1961), American jazz trombonist and band leader
Matthew Mole (born 1991), South African singer, songwriter, and musician
Fictional characters:
Adrian Mole, fictional diarist in a series of comic novels by Sue Townsend
Rosie Mole, Adrian's sister
de Mole
Fanny Elizabeth de Mole (1835–1866), botanical artist of South Australia
George Edward de Mole (1833–1918), public servant in South Australia
Henry William de Mole (1826–1892), Australian businessman
Lancelot Eldin de Mole (1880–1950), Australian engineer and inventor
Violet de Mole (1874–1946), teacher of French in South Australia
Fictional characters:
Mathilde de la Mole in The Red and the Black by Stendhal