Moriguchi (written: 森口 lit. "forest mouth/entry") is a Japanese surname. Notable people with the surname include:
Denise Moriguchi (born 1976), American businesswoman
Fujimatsu Moriguchi (森口 富士松; 1898–1962), Japanese businessman
Hiroko Moriguchi (森口 博子; born 1968), Japanese singer
Kakō Moriguchi (森口 華弘; 1909–2008), Japanese textile artist
Kunihiko Moriguchi (森口 邦彦; born 1941), Japanese textile artist
Sadako Moriguchi (森口 貞子; 1907–2002), American businesswoman
Sumitada Moriguchi (森口 澄士; born 2001), Japanese figure skater
Tomio Moriguchi (森口 富雄; born 1936), American businessman and activist
Yoko Moriguchi (森口 瑤子; born 1966), Japanese actress
Yuko Moriguchi (森口 祐子; born 1955), Japanese golfer